@pharis022 - I am curious if you changed doctors during these medication changes. May I ask what you are on now? Fibromyalgia is an extremely complex illness. I've know several people who have had it. There has been recent breakthroughs using cannabis to treat it. Please know that I am not telling you to take it, but it could be an options for you. https://www.ncbi.nlm.nih.gov/pubmed/29461346 Medications can cause depression and I hope that you go back to your doctor and discuss your present mental health situation. There is no reason to put up with medications that make you depressed.