My doctor prescribed Cholestyramine 2X/day for extreme back and abdomenal itching. At night when my feet and legs itch, I take hydroOXYmine PAM. Together they have helped a lot. I went to dermatologist too, but she the prescribed creams that did nothing. For reference, I was diagnosed with Cirrhosis 2 years ago and have no further symptoms since then. If you get the cholestyramine, I suggest you take it with OJ (it's a powder). Good luck!