Hi, @beebz, and welcome to Mayo Clinic Connect. That would be very hard to have this depression worsening with no medicines helping much to date.

I would like to introduce you to @guener @parus @annedodrill44 @merpreb @stressedmesseddepressed, who may have some ideas on relieving the depression.

Have you tried any other therapies beyond medication thus far, @beebz?