Kris, thanks for the info. I had a discussion on another thread about how going off of estrogen replacement effects the mucosa in the colon. I also researched it online, and there are a couple of solid studies on it. My problems started right about the time my doc took me off estrogen. I've had a tortuous colon since at least 2008, but problems just started 2 years ago...exactly when I went off estrogen. Going to ask the doc to let me go back on estrogen cream, at least.