@hopeful33250 I did my first shot on Thursday under the guidance of a "Clinical Educator" from Tymlos, on Facetime. That went well, my heart rate did not go up, or if it did it was only by a few beats. I tend to have a low heart rate anyway - resting heart rate is about 53 usually. I had a very slight amount of light-headedness for a brief amount of time. I did my second shot last night. I had the same, but I also did have some slight nausea, nothing bad enough for me to be concerned.

I have heard from others that taking it at night is good because then you can go to sleep if you have side-effects, but to do it a bit before you are ready to go to bed because if you have a rapid heartbeat it may interfere with falling asleep. I went to bed about a half hour after taking it and all was well. Hopefully it will continue that way but some people don't get bad side-effects for a number of months.

I am very hopeful. If I do have side-effects I can easily discontinue it, but I hope that does not happen. It's just so darned expensive. I am on Medicare so I used their website to find the drug plan that would be best for the drugs I am taking. That led to a change in drug plans, saving me about $800 a year! The new drug plan does have a hefty deductible though so the first month cost me $900. It will be about $500 next month I think and stay there until I hit the donut hole at which point it will go up, and then down quite a bit when I come out of the other side of the donut hole. I went through this xifaxan when I was pre-transplant too so I am familiar with the coverage.
JK