@sue225 I became very sick for about ten days and initially thought I had a bacterial infection related to my bronchiectasis. Muscle and joint pain followed, persisting for a few months. I had previously been on Prolia and had taken a year holiday to give my body a rest from the medications (and returned to osteoporosis levels). So, I saw a new endocrinologist at Mayo (my previous provider had retired locally) and we had decided to return to Prolia as it had worked well for me. Then, fast forward six months and I fell down some stairs and broke my foot (which involved a long recovery process). The doctor switched my medication to Tymlos for bone building and I initially tolerated it but slowly I began suffering ever increasing leg pain. So, now it’s back to Prolia. I am not considering discontinuing it as I have been on and off these medications and I have not been able to maintain healthy bone density without them. I hope this helps.