@laurapearl, that is really interesting. And such a tremendous increase. I think they likely do trials against a range of sizes and look at average. It's such a new drug that my guess is it will take a while to perform dosing studies. I am not as small as you but below 110 lb, and although I tolerate the dosage fine, but why take more if I don't have to. Also, I wonder if this could effect how long during a life time it could be used. Of course that question can't be answered now, but wonder if you take 1/2 does would 4 years be allowable - that would be especially significant for those of us that use up our time allotment so early in life and cannot tolerate oral bisphosphonates to help in between. I hope your doctor shares with makers of Tymlos. I'm going to share with my endocrinologist to see if any studies are in action. Thanks for sharing.