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Forteo vs. Tymlos: Which did you choose?

Osteoporosis & Bone Health | Last Active: Dec 14 1:41pm | Replies (631)

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@laurapearl

Hi everyone: from what i understand, it may indeed be beneficial to stay on bone-building meds so that you maintain your gains, and my doctor tends to see it this way -- BUT at the same time, there are qualifications that we discussed. We know that most osteoporosis meds work by slowing bone cell turnover, meaning that you retain the bone that you already have for longer (e.g., the bisphosponates, reclast, prolia all work this way). This is definitely a good thing in the short-term, but it can't go on indefinitely. Because you are hanging onto every bone cell for a longer time, the proportion of older bone that you have increases, which can result in brittleness down the road... so these meds are best stopped after a few years AND afterward these bone-resorption-inhibitors do need to be followed up with something else. They have helped your overall density but not actually built new bone, so my doctor recommended only 3 years on Prolia, the first med that i used. (i couldn't start with a bisphosphonate due to GERD.) This is where Forteo or Tymlos can come in -- they are different in that they DO actually stimulate the growth of new bone. Conceptually, it's like you first helped your bones hang onto what they had, and then you filled in the spaces with some stronger brand-new bone. (My dexa scans bear this out. i had a few percentage points of increase every year with Prolia, but then a large increase of 14.5% after the first year of Tymlos.) Forteo and Tymlos can only be taken for two years total. So, after i finish my two years, especially since Tymlos has brought me back into osteopenia, could I consider a drug holiday? My doctor doesn't love that but she feels much more comfortable with a holiday after Tymlos than she did with a holiday after Prolia (which she pretty much ruled out). So that's my tentative plan! One more year of these injections and then perhaps some time off 🙂

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Replies to "Hi everyone: from what i understand, it may indeed be beneficial to stay on bone-building meds..."

@laurapearl Thank you for adding to our knowledge about these different osteoporosis treatment choices. I am a Tymlos user and would be over the top thrilled about a 14.5% scan result. If your doctor isn't too excited about you taking a break, what is being recommended? Is age a factor?
Chris