I am 61 yrs old and finishing my 12th month of Tymlos right now. I have an appointment in 2 weeks with my endocrinologist to discuss what is next. She doesn't think wise to use up the whole 24 month lifetime amount when I'm so young. Since I've had extremes gerd the past 2 years, oral bisphosphonates are out so it is prolia or reclast. I'm probably more anxious about the possible issues with weakening my immune system right now which is a possible side effect prolia therapy, so am leaning towards Reclast. When I discussed my fear of an injection of medicine that lasts 12 months my endo said she can do 6 months at a time. The progress is slightly slower but she has done it that way for others like myself. She also said it was very rare to have any extreme reaction - like being in bed for weeks. I wonder why we can't even do quarterly - has anyone ever hear of that? I am going to ask my endocrinologist. I'd rather take less at a time but maybe less than 6 months isn't strong enough to lock in - I really don't know if it's been studied at all. Also, for anyone considering Prolia it may help to know, my sister did only Prolia for 4-5 yrs and went out of osteoporosis and isn't doing anything now (I believe it's been a few years). She had no bad reaction at all. I do not know her numbers, but her spine was not as bad as mine (-4) to begin with. Like someone said above, it is a lifetime of taking something, at least every few years, but better than years ago when there weren't alternatives other than oral bisphosphonates. Thank you to everyone for sharing - it does help to process.