Hello all, this is my first post but wanted to share my experience with Tymlos in case it is helpful to anyone. I had a terrible reaction after the first injection - nausea, bad headache, aching all over. However, when I woke up the next day I felt perfectly fine except it took every ounce of courage for me to inject myself a second time. But I did and … it was fine. None of the reactions from the previous day. I do have mild heart palpitations from time to time, but have now been on it for 13 months and have never had another reaction like that first evening. I say this in case anyone else has the same dramatic reaction to the first injection - I would suggest you try one more and see how it goes. My DEXA after nine months showed spine improved from 4.0 to 3.1 but little improvement in hip (2.7 to 2.6) or wrist (stayed at 4.0). Like many of you, my doctor wants me to go on Reclast after my Tymlos days are done. And, like many of you, I am reluctant to commit to an annual infusion in case I get a reaction like my first dose of Tymlos, but it doesn't go away.