Hello, I've been on Tymlos 4 months. While my calcium blood tests have improved, I've been told I will have to stay on Tymlos for 18-24 months! The side effects I've experienced are mainly stomach pain and fatigue. Some days, are good and some are quite difficult. Unfortunately, my score was 4.3 and there were not other options that could build bone within a relatively short period of time. The problem is that the Tymlos treatment, if successful, will bring my osteoporosis level to 2.5. This means I have to be on some type of injection or infusion program for the rest of my life. Paper thin bones does not allow for any type of surgery requiring hardware. Only time will tell whether this treatment is successful or not! I do not give myself the injections, my husband does it for me. Since a limited part of the abdomen is the area designated for the shots, a lot of scaring makes self injection quite challenging. Hope this info helps! Sherry