I have been using Tymlos for about 3 months. Totally agree with the people who say a training in person is worth it. I had started with only remote instruction and was having a hard time doing the shots. A wonderful nurse came, sponsored by Tymlos, and it made all the difference. Now it is truly almost nothing. I don't think I have had any side effects. I am exercising and taking vitamin and mineral supplements and a small amount of additional calcium (I am a vegetarian, almost vegan). Hope it is working. I will probably explore soon a provider of multivitamins who has figured out how to time their morning and evening doses to avoid interactions. A friend referred me to the product, I think it is called nutreince, but I don't know yet how good it is. Still investigating. Reading all this thread makes me want to check with the Tymlos support line to see whether there might be new results suggesting a particular time of day is best. Like most others, I prefer nighttime, rather than adding to the morning rush. Up until now, I have not seen anything about it specifically for this product, which is different enough from Forteo to make me not want to generalize. Will let you know what they tell me.