Hi Rabab. I have stage 4 Invasive Ductal Carcinoma. I was diagnosed "denovo" (stage 4 right from first diagnosis). I take Letrozole with my other meds and found the achy joints dissipated after awhile (7 months or so). I have also experienced hair thinning that started about that far in and then stopped, but has restarted. I know there are other Aromatase Inhibitors out there that you may want to check into to see if they would have a lesser affect on you. Personally, I recommend taking them and hope you never get to stage 4. Side note: I am doing terrific on Ibrance/Letrozole and shots for my bones as my cancer is in my femurs, humerus, and lungs. All are shrinking and I lead the same life as I did prior, no changes and I'm just coming up on 2 years. I wish you all the best!
Peggie