Thanks for your reply. I can so relate. I'm 64 now. Husband is ok but sometimes loses patience...."Oh, go back. I forgot my list"! I will see how it goes as I don't know how much of my depression/brain fog is cancer fear and/or Covid fear! Life did hand us a curveball this past year! I'm due for the Covid vaccine soon so hopefully that will give me a little mental break. Other than the brain fog, worse at some times than others, and tight finger joints upon waking, I don't have many other side effects, at least not that I know of now, thank God. I'm just worried since I have some genetic links to dementia that AI's may exacerbate it and memory won't come back fully after discontinuing. It would be interesting to know if anyone did the 5-year course of AI with brain fog/memory issues and how they fared after discontinuing, i.e., did the brain fog lift or were they permanently impaired. Thank you all for sharing your insight and experience.