I took them for 6 months and the side effects were crippling. It has been 11 weeks now and I am clear headed, sleeping better, still have stiff joints and fingers not bending at all, but those are also side effects of radiation. I now take DIM plus, calcium, Vd3, selenium, Ve, garlic, and an immunotherapy vitamin. Have felt 80% better and improving every day. Went for mammo (1 yr) and ultrasound and should hear from Dr tomorrow. I will not put that poison in my body. It causes too many other issues. The starvation of all estrogen to the brain in that short time has now caused head tremors. No way.