@kathyomaha55 For me, the switching from anastrozole to letrozole and then finally to exemestane has been better. I'm at 1 year down and 9 to go, but I keep telling my husband that I'd love to just quit altogether. I initially had invasive ductal breast cancer and second tumor was neuroendocrine so unfortunately the odds are not good if I go off of the exemestane. I really cannot complain as I have two friends in my support group who have metastatic breast cancer and one just recently died.