The rash started after I had been on Keppra for about 18 months. We tried another med that had worse rashes. My neurologist says "All anti-seizure meds have rashes as a side effect." I am more concerned about the depressive symptoms as I already was depressed before I developed seizures. While I have been seizure-free on 1500 mg. of Keppra a day, the depression is debilitating; good thing I'm 77 and no longer working!