I have been on Duloxetine 120 mg for several years. Recently I had eye surgery with the complication of abnormal bleeding into the vitreous fluid in my eye. I mentioned this to my psychiatrist and he looked up adverse effects. There is a rare instance of abnormal platelet agglutination being on Duloxetine. My psychiatrist stopped 60 mg of the drug which I did fine with. About 10 days ago he told me to stop taking the other 60 mg. I have a diagnosis of major depression with anxiety disorder. I received upsetting news about my son while out of town about 5 days after being off Duloxetine. I had a volatile anxiety/depression crisis with crying, severe anxiety, and deep depression. So it has been 10 days since I’ve been off the Duloxetine and the brain zaps, the prickling skin sensations, air hunger, the increasing anxiety, abdominal pain, nausea, confusion, and feeling like I’m in outer space are worsening daily. Of corse it’s Saturday and I am unable to reach my psychiatrist. I am taking my clonazepam which helps with the anxiety for now but I have had to take 1 more pill than ordered to keep me from losing it. I have 20 mg caps of Duloxetine but I don’t want to do anything without my doctors orders. I am having a hematology consult next Wednesday. I wish my doctor would call but his office recording doesn’t mention an on call Dr and my doctor’s cell phone mailbox is full so I can’t leave a message.