Hello Jim, Chemo works very well with SQ Cell. I had 38 treatments of radiation that almost killed me. I had a tumor under my right jaw and 4.5 years later had SQ Cell in my right tonsil. I underwent Chemo at the ND Cancer center, and then continued with radiation. I also had left and right radical neck dissections. If I could do things over I would not have the surgery, because the Chemo worked so well. Every case is different, all I can tell you is what I did and now in hind-sight, tell you what I should have done. Pray about it, and let the real Doctor advise you. After all, He knows better than anyone!