There's a lot of loose talk about ACE Inhibitors causing angioedema. I got interested in this side of the issue after 10 years of Lisinopril medication without incident. I have several acquaintances who have been similarly free of angioedema consequences of ACE inhibitors.

Here's a quote from a respected case study: "Angiotensin-converting enzyme inhibitors are the leading cause of drug induced angioedema. Angiotensin-converting enzyme inhibitors induced angioedema is a class effect that can affect between 0.1% and 0.5% of patients taking the drug." [https://casesjournal.biomedcentral.com/articles/10.4076/1757-1626-2-7181]

Some people read only the first sentence and see "leading cause of drug induced angioedema." But that consequence is rare, and the "leading cause of angioedema" amounts to no more than 0,5% of patients taking Lisinopril or another ACE inhibitor. That's one-half of one percent or one in 200 cases and may be as low as one in 1,000 cases (0.1% of cases).

When I started on Lisinopril, my nephrologist noted that I had swollen ankles and told me this condition probably was attributable to another medication -- a calcium-channel blocker. Shortly, she took me off that medication, and the edema in my ankles disappeared, although I have been on Lisinopril ever since. I am not one of the rare cases of angioedema caused by an ACE inhibitor. Perhaps you are. I hope you get the right answer soon and get the problem behind you.