Hello @barnowl53 ...... after I read your posting, I had to reply. I can empathize with you, I’ve been seeing a psychiatrist/psychopharmacologist for 22 years. I have tried around 20 different meds and combinations. They start out working, then peter out, now I’m on trintellix. So far, so good. Please don’t give up! You are a worthwhile human being! There are others like you. You are definitely not alone!