@nicoleny Just to reinforce. All Amyloidosis is progressive and, eventually, fatal. It may not reach the fatal level until age 90 or 140. But eventually it will take you if nothing else does. It just depends on how it starts and the pattern it holds, and how you block it. The enlarged liver means only that you should 1) have a liver biopsy, and do it again in another year, and 2) have the sFLC every year, and if it shows above the reference range for Kappa OR Lambda OR both, do the serious testing as soon as possible as noted in my paper or named by Mayo or other 1-AAA Clinic.