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Pembrolizumab (Keytruda), Cannabis and Cannabinoids

Lung Cancer | Last Active: Jul 18, 2022 | Replies (24)

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@robin47

Hi Everyone,

MY dad has stage 3B lung cancer and he went through chemo radio , surgery but it came back then he was on Keytruda and Chemo we had %70 success in the mid of treatment but then suddenly he got infection and couldnt keep going on treatment for 6 weeks then he completed but scan result came out the size of tumor actually increased compare to previous one. then he was on another chemo and after that was completed the test result was stable and now he is on Opdivo he just took the first one and I also provided him thc oil but some research says its not good to give both at same time. I do know what to do? anyone used both at same time?

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Replies to "Hi Everyone, MY dad has stage 3B lung cancer and he went through chemo radio ,..."

I am stage 4 mesothelioma. I am using Keytruda and THC at the same time. I used THC for over 4 months now, and only started the Keytruda treatment last week. My oncologist didn't stop me using the oil. He said current research study is limited and no conclusion to strongly suggest one way or the other.

@robin47- Welcome to Mayo Connect. I am not sure why your post was not answered in December. I just received it. I apologize for this oversight.
I'm so sorry that your dad is going through this. It must be very very difficult to feel so helpless. Are you his main caretaker? I am a lung cancer survivor but I never had immunotherapy. What type of lung cancer does he have? Small cell (SCLC) or non-small cell (NSCLC)?
I think that you can google Opdivo and see the side effects and how to avoid some of them, if your dad experiences them.
https://www.opdivo.com/
There is some research that indicates that CBD oil interferes with immunotherapy. And as you know, the use of CBD oil and how it interacts with other drugs is far from giving us definitive answers.
- https://www.oncologynurseadvisor.com/general-oncology/cannabis-reduces-immunotherapy-response/article/688059/
- https://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/The-effect-of-cannabis-use-on-tumor-response-to-Nivolumab-in-patients-with-advanced-malignancies
- https://www.medicaljane.com/2014/08/28/study-cannabinoids-may-increase-lung-cancers-susceptibilty-to-specialized-killer-cells/

The ultimate decision will be up to your dad. Have you asked him about this? What does he want to do? As a cancer survivor of 21 years (NSCLC) I can tell you that unless a cancer patient can not answer questions all decisions should be made by the cancer patient. It is his/her power. I'm sure that you know this.
Please get back to me and let me know if what your dad's decision is. My best, Merry