Hi, @terri672 - I moved your post to this existing discussion on effects after tapering off venlafaxine (Effexor) so that you could connect with others discussing this subject. Click VIEW & REPLY in your email notification to get to your post.

Hoping that @sandij @ldwhite720 @texasduchess @brightwings @notaround @babydoll will chime in with any experiences they have with returning depression or anxiety after a taper off of venlafaxine (Effexor).

What symptoms are you noticing especially with the depression and anxiety, @terri672 (e.g., loss of interest in activities, restlessness, trouble concentrating)?

@terri672
I was only on Effexor (25mg regular release) for hot flashes. I never had anxiety, insomnia, akathisia, irritability and rage UNTIL I tapered off (last dose was 4/14/18). Effexor increases/regulates the levels of two brain neurotransmitters--norepinephrine (noradrenaline) and serotonin. At low doses, it prevents serotonin reuptake (leaves more serotonin in the system). At higher doses, it inhibits both serotonin and noradrenaline reuptake. Serotonin helps control a number of processes within the brain--mood and emotions, anxiety and aggression, sleep, appetite, memory and perceptions. Norepinephrine is a stress hormone that affects parts of the brain that relate to attention and response and it underlies the fight-or-flight response. I realized pretty quickly that the overwhelming feelings, insomnia and akathisia were Effexor withdrawal symptoms. It's going to take some time for my brain to balance itself (I was on Effexor for 18 years); I found relief in taking supplements (click on my name to read past posts where I list them). If you were on Effexor for mental/emotional issues, you may need to go back on it, or try a different medication.

Effexor has damaged my vision & other parts of my brain. Motor control of my extremities. E.g shakes, handwriting, coordination etc.