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I know knee replacement is in my future in a few years, but because of all my allergies I am concerned about a reaction like you are dealing with. Because of your post I now have more homework to study what is- typtase and mastocytosis or mast cell disease is. I feared an allergic reaction to the synthetic mesh put in 3 years ago to tie up bladder prolapse and was told it would be safe and it was. Great successful results! But putting foreign substances in my body is a gamble and would rather use a walker than deal with the misery of 24/7 itching and raised inflammation level pain which is inescapable. I know, I have been there. I will pray for you mrshonesty (love your blogging name), prayers helped me with a miracle cure for an autoimmune disease I got at age 50 disappeared totally 5 years ago- gone! Shouldn't have happened according to medical science.
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@gardeningjunkie With the problems you have had it's very smart to check all of this out. I would hope that with some testing beforehand, and then making sure the replacement is made from a metal that you are not allergic to, you would not have a problem. I do have some metal allergies but never thought of this, I assumed it was made of a metal that was non-allergenic. I have two knee replacements, different brands, but that has never been a problem with either.
I believe nickel is the most common metal allergy so I cannot imagine that something being put in a body would be made of nickel. Dental implants are often made of titanium, but even that can cause allergies in some people.
I hope when you eventually have TKRs, that they will be successful and allergy and pain free.
JK
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@gardenjunkie When your ready for any replacements check out what the knee ,hip or others are made of remember reading about the recent problems people had