Welcome to Connect, @johnny17
I'm connecting you @lorenamaher, who is living with primary lateral sclerosis (PLS).

Are you familiar with NORD (National Organization for Rare Diseases)? Here is their information page on PLS. At the bottom of the page are current investigational therapies https://rarediseases.org/rare-diseases/primary-lateral-sclerosis/

Additionally, I found these studies at
- Mayo Clinic https://www.mayo.edu/research/clinical-trials/search-results?keyword=Primary%20lateral%20sclerosis
- NIH https://www.ninds.nih.gov/Disorders/All-Disorders/Primary-Lateral-Sclerosis-Information-Page#disorders-r2

May I ask how old your brother is? Do you live near him?