@karjack I was on Nexium for over a decade ... then after I had a disastrous Nissen surgery (in IA, not at Mayo) to reduce GERD, I was finally diagnosed with Gastroparesis when I asked to be referred to Mayo MN. The GI doctor there prescribed Esomeprazole Magnesium (20 mg).. That was about 5 years ago.. It works, but it does not allow you not to take the physical precautions like sitting vertical for at least 2 hours after eating and sleeping on an incline.. to keep the stomach acids/and food from coming up.... The GI doctor at Mayo gave me no indication that I will ever get off that medication.. He also prescribed Mirtazapine, "to make me think that I want to eat ... " ... I have gained back 25 of the 50 pounds I lost during the struggle after that Nissen Surgery... so I am at a decent weight now.. lean and mean as we would say in the Corps.. Ken