@kozlo52 and @tigreyes2004, I apologize for jumping into the middle of this thread and maybe this question has already been addressed, but in regards to your friend being on gabapentin, that seems like a massive dosage she's taking - how long has she been taking it, and has she told either her prescribing Dr or another one of her Drs about the memory loss, and if so, what did they say? I'm definitely interested bc I have been on Gabapentin for a year now, but only 300 mg, twice a day, and 100-200 mg once a day (so that's 700-800 mg total each day). I take it for many diagnoses, including pelvic floor dysfunction, IBS-C&D, Interstitial cystitis, and fibromyalgia, as a nerve relaxer to help with chronic pain that stems from all of those. I have also been on other meds like Cyclobenzaprine 5 mg (flexoril) (muscle relaxer) daily, and Oxybutinin 5 mg as needed for bladder spasms from the Interstitial cystitis. So, I was also wondering if your friend is taking any other meds that could either be the culprit of her memory loss, or ganging up with the gabapentin to cause her memory loss. I just turned 45, but have always had memory problems; my Dr says it's probably caused by stress; however, I definitely (as well as my family) have also noticed my memory getting worse since being on these various meds, so I was just curious to find out more about your friend, and if she has found anything out about her memory loss. As far as the weight gain goes while taking Gabapentin, I've actually lost weight since being on it. Because of my IBS and IC, I've had to be on the Low FODMAP diet as well as an IC diet (low to no acid diet), and so thankfully, the gabapentin hasn't gotten me there! I went from weighing 123 (I'm only 4'8"), to weighing 92 lbs. My Dr actually has me trying to gain now, so I believe at my last appointment I had gained a whopping 3 pounds, ha! Anyway, thank you for any more information that you can give me.