Hi @nightngale1998 and members in this discussion,

I thought you might be interested in reading this recent article published in the journal of Gastroenterology:
– https://www.gastrojournal.org/article/S0016-5085(17)35623-8/fulltext

Based upon numerous studies which evaluated the long-term use of PPIs like Omeprazole, researchers conclude that (copied):

– Despite the recent alarm generated by some high-profile, newsworthy publications, few (if any) of the recent scare stories have attempted to balance the benefits of PPIs with their alleged risks.
– A great number of patients are receiving PPIs unnecessarily for conditions or symptoms for which they would not have been expected to provide benefit. Furthermore, many patients who are on PPI treatment for appropriate indications are receiving excessively high daily doses.
– For some patients, treatment may need to be lifelong. However, multiple “false alarms” related to the safety of PPIs could ultimately lead to inappropriate discontinuation of treatment with potentially serious consequences for some patients.
– Much of the current evidence linking PPI use to serious long-term adverse consequences is weak and insubstantial. It should not deter prescribers from using appropriate doses of PPIs for appropriate indications.