@flannelette, There are many variables to be considered when choosing a CBD:THC ratio for medical cannabis. Here is a pretty up to date discussion on cannabis.net. https://cannabis.net/blog/medical/what-are-cbdthc-ratios-and-their-benefits . I trust independent information and not that promoted by a manufacturer or distributor. So... for me...the 2:1 CBD-THC ratio is best when I am easing in to a day that started with gentle yoga and meditation. Based upon how the day progresses in terms of pain and pain-related anxiety levels, I often switch to a 1:1 ratio in the afternoon. Not to make this more confusing but just to provide personal dosage information, I use a 1:3 CBD-THC vape oil for what might be called break-through or ramping up pain during the day because the relief is immediate. And then, I find that a return to a sublingual tincture of 2:1 as I go to bed ensures a more restful sleep. I have been exploring the world of non-addicting pain remedies to include types of medical cannabis and dosages for about three years now. The product options and quality are improving, the delivery systems are more reliable and the research studies from honest, independent sources are evolving and becoming more encouraging. Personally, I am committed to staying as up-to-date as possible. My quality of life and over-all happiness depend on it. And I wish that same quality of life for you.