I wanted to share my experience with Lupron as well. I was originally treated in 2015 with Stage T2a prostate cancer with external beam radiation, Firmagon, and brachytherapy (66 seeds). PSA remained low until August of 2018, then it went up, went down, then up again to 9.5. So I was prescribed six sessions of chemo (taxotere) which I completed in July, and I am supposed to be on Lupron the rest of my lfie, one shot every three months (I am 62). After recovering from the fatigue and hair loss side effects of chemo --- fatigue is almost gone, hair is coming back --- I am now experiencing those classic side effects of Lupron --- muscle loss, frequent urination, though the hot flashes are not as bad as they were originally, they are still there. It's rare to be able to sleep through a full night without a trip to the bathroom, though I have done it once or twice. My longer-term goal would be to get off the Lupron if I can, if a new drug, perhaps other than Zytiga, is developed.