What kind of extreme side effects did you have and how soon? I have just started Lupron this last Wed. My prostate was removed 10 years ago and I had external beam radiation that same year. Recently my psa went from 2.8 to 6.22 in 6 months and a bone scan found that it has shown up in 5 spots in my bones. One spot in my left shoulder, one rib, both pelvis and the prostate bed area I think. I am seeing an oncologist this coming Wed to see what else they recommend. My urologist thinks they will recommend chemo. Understand there are at least 3 options and I don't know what to expect.