@baumgrenze - I think this thread just went dormant last summer as no one seemed to have anything to add. I have called this thing RLS or PLMD, sometimes I think it may come from the spine. Evenings when I try to relax, the leg starts to spasm. (That's when I think it is RLS). I do take Requip, a Parkinson drug, in the evenings and at bedtime. Trying to prevent the spasms, I take three meds about 5pm: Gabapentin, Tramadol and Requip. A sitting position in the evenings does NOT seem to help, having my back flat seems to help more, but that is probably more an individual thing. Also - I have a painful stretch along thigh (maybe along I-T band? or possibly post herpetic neuralgia?) from hip to knee - sounds like you? I do notice that when the outer thigh seems sore I have more pain and movement. This offers no help - but possible working together we might find something that does help.