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Renal cell cancer: Anyone else with this cancer?
Kidney Cancer | Last Active: Nov 17, 2018 | Replies (13)Comment receiving replies
Hi Guys, thank you so much for all the reply.
I did my own research, and found 2 clinical trials that might have a better outcome which is:
– Javelin Renal 101 (phase 3 trial) Combining "Avelumab and Axitinib" By Dr Robert Motzer from Memorial Sloan Kettering Cancer Center, New York
this study might has a more promising result:
Objective response rate 55%
Progression free survival 13,8 months
However, I cannot find the Complete Response Rate (probably around 5% from another source)
– Keynote 426, Combining "Pembrolizumab and Axitinib" Randomized trials by Merck and Pfizer (Phase 3 trial On going). However the phase 1b trial shows that:
Objective Response rate 73%
Progression free survival 20 months
Complete Response rate 7%
Compared to the 2 options given by the Singapore Oncologist:
– Combination of "Ipilimumab + Nivolumab"
Objective response rate 43%
Progression free survival 11,8 months
Complete response rate 9%
Adverse event could be organs failure
– Sunitinib
Objective Response rate 27% ( in intermediate and poorer risk group)
Progression Free Survival 8,4 months
Complete Response Rate 1%
However, the avelumab axitinib and Pembrolizumab axitinib are not available in Indonesia or SIngapore as my nearest developed country. has anyone know about this trial or has anyone experience this trial?
i have told also that immunotherapy could have a fatal side effect. is that true?
immunotherapy cost is super expensive in singapore, or maybe considering i am indonesian a developing country. 1 USD is 15000 Indonesian rupiah. the cost of immunotherapy in SIngapore is more than USD100.000/ 4 injection.
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I was diagnosed with kidney cancer, metasticized to bone (left acetabulum) in June, 2013. My left kidney was immediately removed and left acetabulum was treated with radiation. I was shortly thereafter put on sunutinib, 1 tab per day for 28 days, then 14 days off. After a few months, I began having severe reactions to the sunutinib, so my oncologist reduced my prescription to one tab every other day for 28 days, 14 days off. In March, 2018, I began experiencing sore throat symptoms and my oncologist prescribed an antibiotic after a month, my sore throat had not gone away, so he prescribed another antibiotic round. In June I underwent a c/t scan and my kidney cancer had spread to my right lung. My oncologist stopped sunutinib and went to Opdivo infusions. After two treatments, another c/t scan showed the cancer in my lung had spread to both lungs, so he advised me to stop the Opdivo and prescribed Cabozantinib. Due to my anticipation that Opdivo would be effective, I was not certain I agreed with this, so I got a second opinion from OHSU in Portland, OR. While there, the oncologist from who I was getting the second opinion noticed my throat issue and referred me to a throat specialist who took a sample to have analized. The "sore throat" was actually squamous cell carcinoma, HPV, making it easier to cure. The decision among the three oncologists was to continue my treatment with Opdivo and radiate the squamous cell in my throat, a somewhat grueling experience. I am, just now, beginning the radiation treatments.