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Overmedication with cancer and other conditions

Head & Neck Cancer | Last Active: Sep 23, 2018 | Replies (62)

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@colleenyoung

Many of you mentioned the role of the pharmacist as part of your care team and had specific questions. Well, I showed this thread to a Mayo Clinic pharmacist and she was glad to have the opportunity to weigh in. Here what she offered:

"Having a list of current medications, conditions and significant medical history and keeping that list updated and with you especially at medical appointments is such a helpful habit. You never know when it could literally save your life. Many smart phones also offer a medical alert app or function where this information can be stored and even accessed by paramedics in case of emergency. There are pros and cons to storing a list electronically vs. on paper. Ultimately it is a personal preference. MyMedSchedule (http://www.mymedschedule.com/) is one example of an app that allows you to enter and modify medications.

Important tips
1. When making your medication list make sure you know why you’re taking each medication. For example, if you’re taking a stool softener to prevent constipation with opioids and are no longer taking opioids, you can probably stop the stool softener. Sometimes this can be apparent to the healthcare providers, but missed by patients who don’t understand what their medications are for.

2. It’s important to clarify with your provider when new medications are started if they will be replacing older medications or taken in addition. Some patients require multiple medications to manage the same condition and that’s okay. Sometimes medications are started with the intent to reduce or eliminate existing medications but for a variety of reasons this doesn’t happen.

3. Filling all of your medications at one pharmacy can help reduce risks. A pharmacist may notice duplications, omissions or interactions that care providers aren’t aware of. This can happen when there are multiple providers involved in your care or when medication changes are limited in acute care situations.

Pharmacists know when to look more closely at a medication regimen to ensure optimal therapy. Pharmacists can help weigh the importance of drug interactions against the benefit of the medication in collaboration with other patient care providers.

In many cases there is quite a bit of room for variation which is why many dosage forms are in set strengths like 20 mg, 40 mg. That being said we are entering the age of individualized medicine where precision medicine, especially for cancer, transplant and other specialties, is becoming more and more accessible. In the age of cellular medicine and CAR-T it doesn’t seem too far of a stretch that we will someday have much less trial and error and more personalized preventative medicine that optimally treat or cure diseases even before we experience symptoms.

Patients with very complicated medication regimens may qualify for medication therapy management which is a service offered by Pharmacists at Mayo Clinic. You can hear more about this service by listening to a podcast here https://newsnetwork.mayoclinic.org/discussion/medication-management/

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Replies to "Many of you mentioned the role of the pharmacist as part of your care team and..."

@lisakuehl The Mayo Clinic pharmacist also added:

"Dosing recommendations can vary based on the medication.
- Weight: Some medications are more significantly weight based like heparins whereas many others are currently one-size-fits-all or titrated to effect by the clinician.

- Genetics: As we learn more about how our genes play a role in our response to different medications, having pharmacogenetics testing can help to reduce trial and error with dosing and suggest a more appropriate starting dose or perhaps dictate that a different medication or therapy is warranted all together.

- Age and Organ Function: As we age our bodies eliminate drugs differently as end-organ function declines. Often drugs are needed in smaller doses as we age because kidney and other organ function decreases. We begin to eliminate many drugs much less efficiently than a younger person with healthier organs. This is more important in certain drugs where precision dosing is indicated.

- Other Factors: Remember that there are often other factors that determine the dose our bodies actually receive including what we have to eat or drink with the medication and the pH associated with drug absorption.