← Return to Using CBD oil to help taper off anxiety & depression meds?

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@swimjay

Something I'm wondering about, re using CBD to help with tapering off (in my case) Clonazepam -- CBD inhibits the activity of the Cytochrome P450 enzyme group in the liver, which ordinarily metabolizes away the benzos and many other drugs after they've been in the body for a while. So, when CBD is present, many drugs persist in the body longer, and have more effect, than they would without CBD present. The benzos are listed as one of the drug classes with which CBD interacts in this way -- so couldn't they be potentiating the benzos, making them last longer in the system, and have more effect, than they would otherwise? (Grapefruit is another, more widely known Cytochrome P450 inhibitor, which is why we don't eat grapefruit when taking tetracycline, for example).
Does anyone have any idea how significant this would be for the use of CBD to help with weaning off Clonazepam?

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Replies to "Something I'm wondering about, re using CBD to help with tapering off (in my case) Clonazepam..."

Hi, @swimjay, and welcome to Mayo Clinic Connect. Just thought you might also be interested in checking out this thread, "Klonopin taper," https://connect.mayoclinic.org/discussion/klonopin-taper

I've been on and off benzos for years..now down to 2mg Valium. I've been using pure CBD the last few weeks to assist. The CBD does not seem to prolong the effect of VAlium at least at my low dose.