I have used CBD tincture 20:1 for the past 4 months that has a very small amount of THC in it to assist in weaning my son with autism off his poly pharmacy that he has been on for many years. 1 dropperful contains 9.5mg CBD to.5mg THC I so far have successfully weaned my son off 2 prescriptions which dealt with his extreme anxiety- Clonazapam and Guanficine. His extreme anxiety often triggered serious behaviors in the past . Initially I weaned him off Guanficine while substituting the CBD oil. I then weaned him very slowly off clonazepam while giving him the cbd tincture generally 2-3 times/day. This is a trial and error method and there is no hard and fast methodology to guide a person in dosing. I am having his staff take behavioral data since we began the CBD and started taking him off the other prescription drugs. We are now very slowly weaning him off an atypical anti psychotic. His behaviors have decreased significantly. He is not as anxious or perseverative or irritable and I, his staff and him are so far very encouraged. The CBD oil seems to last about 4-6 hours. The medical marijuana dispensary people were very helpful but it is all anecdotal data at this point. You need to make sure you find a reputable company and dispensary There is some scientific evidence to show that CBD may be impacting GABA receptors or others but we need a lot of research. We need the FDA to change its policy of having medicinal marijuana as a Schedule 1 drug since this is preventing the research. I am not too worried about any potential side effects from the CBD but I am very careful about the amount of THC given, as that has been known to sometimes cause psychotic episodes if too much THC. . If anyone has information on weaning off atypical antipsychotic medication I would be most appreciative . Hopefully the CBD oil will make these other medications unnecessary since they seem to have many more long term side effects than the CBD.