Hi Collen, thanks for linking the prior exchanges with my post. Yes, we've used the Epidiolex CBD oil (FDA approved in 2018) since January '20. Started with 1ML 2X/day, and based on his body weight (143lbs), doctor recommended we gradually increase up to 3ML, 2X/day. The doctor's thoughts were to reduce/remove the zonisamide med altogether by reducing the dosage down as we increased the oil. When we removed the 50mg of the 100mg dosage of zonisamide, ~4-days later he experienced two grand mal seizures in the afternoon of the same day (we returned back to 100mg dosage). We found that at 3ML-2X/day dosage he experienced diarrhea and drooling episodes, recognized side-effects, so we adjusted to 2ML in A.M. and 3ML in P.M., and have been at that dosage since early April '20. Maybe my expectations were that the oil would have a more dramatic response like arresting the myoclonic jerks/quick-bursts and possibly eliminate/control grand mal events. In addition, possibly allow removal of one, if not both AED's.