Hi all,

I think most of us would do without meds if given the option, but sometimes they are necessary. You might be interested in going through some of these recently published studies and clinical findings. New research shows no direct correlation between the use of PPIs and cognitive or mental decline.

– Setting the record straight: PPIs do not cause Dementia (Association Between Proton Pump Inhibitor Use and Cognitive Function in Women) https://www.sciencedirect.com/science/article/pii/S0016508517359103?via%3Dihub
– New Study Disputes Claim That Heartburn Meds Raise Dementia Risk (Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia) https://onlinelibrary.wiley.com/doi/10.1111/jgs.14956
– Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883984/

Researchers also found those who used PPIs were at a lower risk of a decline in cognitive skills. A large 2016 German study concluded that people taking PPIs (and statins) had a lower chance of dementia.
– https://www.ncbi.nlm.nih.gov/pubmed/26744954

However, it is important to note that some possible cognitive effects of PPIs can be due to drug interactions, especially in elderly patients. Those who used PPIs were also more likely to use anticholinergic medicines – medications used to treat incontinence, depression and sleep problems and include diphenhydramine (Benadryl) – that have been linked to thinking difficulties. For instance,
– omeprazole may increase blood levels of diazepam https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671798/
– an FDA study has shown that some adverse events with PPIs could be associated with benzodiazepine drug interactions http://bit.ly/2KyiHID

I hope this helps.