A question I have. Why did you go off antidepressants if they were working? I should say why do we go off a medication that is working. Several years ago I was taking Zypexia for depression. I took it for at least 3 years and it worked well. The problem was weight gain. alot of weight gain through the years. I weaned off of it, but it was hell.I am not sure if my brain still mourns for it. Again the reason was unhealthy weight gain. I did lose the extra weight plus because I was so sick. I also took Zoloft for until about 2 months ago when the doctors believed the Zoloft to cause hypoglycemia. I am not diabetic. Right now I am taking Effexor 37.5 and Elavil 50mg at night. The elavil was prescribed because of chronic pain from fibromyalgia. I do believe the elavil helps with pain and sleep. I also use Percocet for osteo arthritis . I do not believe I will never have to take an antidepressant and if one works without serious side effects I will stay on. I am just not sure of anything right now. My husband died Jan. 7, 2018 and I am still somewhat of a mess.