I'm assuming by "isolate" CBD, you mean CBD without any THC. I have only used CBD Living Water that I think has no THC in it. I used it when I was withdrawing from Tramadol. It really helped me with the anxiety that comes from withdrawal. I just felt relaxed when I used it. I only use the CBD w/1/4 THC now, .50 on the dropper, and it works for me with no "high" feeling. Everyone is different though, so you will have to find the dose that works best for you. Start at .25 on the dropper and work your way up from there.