I have taken omperazole  20 mg once a day for ten years from 2008 to 2018. Then when I went to low dysplasia, I was upped to 40 mg twice a day. I was concerned but was told that because I had BE, I must take it. So, what can I do. So far, I don’t seem to have further issues from the medicine. I now have  switched to protonix 40 mg twice a day. I can’t tell a difference in the medicine. It seems to work.