Hi, @mrector - sounds like through this process of dealing with the arthritis and bulging disc in your back, you are looking out for yourself and taking care with your medications, especially with your history of brain tumor.

Here is some pertinent Mayo Clinic information about tramadol and interactions - see the Drug Interactions section https://www.mayoclinic.org/drugs-supplements/tramadol-oral-route/before-using/drg-20068050

Perhaps the best route at this point would be to go back to the doctor you are seeing who prescribed the Tramadol for a discussion on taking this if you have a brain tumor and whether this medication and the fluoxetine (Prozac) you are taking can cause a reaction (or is required despite this). Would it be possible to contact this doctor tomorrow? Are you finding anything that provides any relief in the meantime?

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