Hi, @mrector - sounds like through this process of dealing with the arthritis and bulging disc in your back, you are looking out for yourself and taking care with your medications, especially with your history of brain tumor.

Here is some pertinent Mayo Clinic information about tramadol and interactions - see the Drug Interactions section https://www.mayoclinic.org/drugs-supplements/tramadol-oral-route/before-using/drg-20068050

Perhaps the best route at this point would be to go back to the doctor you are seeing who prescribed the Tramadol for a discussion on taking this if you have a brain tumor and whether this medication and the fluoxetine (Prozac) you are taking can cause a reaction (or is required despite this). Would it be possible to contact this doctor tomorrow? Are you finding anything that provides any relief in the meantime?

@mrector
Hi Mandy,
Yes it’s absolutely true. Your very wise heeding your pharmacists warnings. My Neurologist cautioned me about it because it can increase seizure activity, my nemesis. It can have interactions with Antibiotics and some blood thinners. There have been cases where people have died. I believe that is rare.
There are some effective NSAID meds. I took Vioxx and switched to Celebrex after Vioxx was banned. Vioxx was an awesome medication except for killing 60,000 or so people. Feldene was a good drug that helped me. Although you need to be aware of long term NSAID use especially if your older. Possible kidney failure, ulcers, heart attacks and stroke among other less serious problems. However I don’t know how much is safe but your doctor will. You might want to see a Rheumatologist.
Hope you find something safe and effective that controls your pain.
Health and happiness,
Jake