Mostly supplements, I am currently on 12.5Mg in AM and 12.5Mg in PM. I know that's not very much but I can feel the change 1-2 hours after taking the medicine. Been on it for 5 years prescribed up to 50MG crashed big time. Lots of changes in prescription over this time. Crashed (very bad response/side effects) almost every time. Had to reduce it myself after research to the 12.5Mg AM/PM while doctors watched. Key supplements, CoQ-10, Multi, D3, Stopped the Hemp oil for the last month still had dizzy spells. Had very bad reaction to Metoprolol that put me in the hospital. Key factor; I have a narrowing of an artery up the back of my neck. If I can find a doctor I have documented almost everything since the operation. One cardiologist commented, "We don't have a clue of what is going on."