Lichen Sclerosis is an autoimmune condition. I once used Clobetasol for a week or so but did not work for me. I now use Betamethasone DP AUG 0.05% and Vagifem 10 MCG-- twice a week. It took a few months to get it to where it came under control. Also, Amitripline 10mg every day. Amitripline is used for depression but it was learned that it helped with LS.

@suzeebee, I did find the following information that may provide an answer for your question.

What Are the Long-Term Effects of Clobetasol Propionate?
-- http://skin.emedtv.com/clobetasol-propionate/clobetasol-propionate-side-effects-p3.html

John

Thanks for the reply & info. Clobetasol is all I've ever used and it does work for me but I began thinking it may not be safe over many years. I had such a large amount of ointment prescribed, I've not gone back to the gynecologist. Seems to me many on this site have many more problems controlling this condition than I do, although I know it will not go away on it's own, so must continue to treat it.

Sue G
I have been using Clobetadol ointment for about 10 yrs. I get lesions, itching, and burning. I use the Clobetasol twice a week. If I have a bad flare, I use it every day for three or four days.
Tammy 🙂

@suzbee227 Clobetasol cause itching and thinning of my skin. Did not help me.