My Mother had a triple bypass and a myectomy recently in Rochester MN. We had the same anxiety nervousness as you. Not knowing the area or what to expect. But let me reassure you it was a wonderful experience. Not one bad mishap at all.
Make sure you do not book your Motel through a booking agent as it makes the price of your room per night more. Call the motel directly to reserve your room. Make sure the motel is affiliated with the Mayo clinic , there will be a discount and they provide a shuttle service, not only to the clinic but St.Marys hospital as well then back to your motel. The motel will provide you with a schedule. Only a few times did we have to take a cab due to unexpected appointments or no shuttle service on weekends. The average cab ride was around 9 dollars.
The clinic was extremely easy to navigate. They also provide wheelchairs for those who need them right at the front door. There are information desks if you have any questions. But the staff including Doctors I stopped in the hallways were always more than happy to give directions. But dont be afraid to ask.
Food was pricey. So we just went to the local grocery store closest to the motel. Hi-V had a wonderful deli , tons to choose from. Little chinese restaraunt inside it, a very nice store. My Mom had one appointment after another , there was very little time to stop in the cafeteria at the clinic so we just took snacks , sandwiches etc. And ate when we could. At the Mayo clinic there are stores to buy drinks , snacks that are cheaper then the cafeteria.
I hope this may have helped you some, after the first couple days you will become an ol pro at getting around. I pray everything goes well with whatever you are having done. God Bless.