@reagan1mc Well, Regan, I don't know all there is to know about this, and surviving, but consider the facts. First, you were born with this. Certainly one of the first pieces of "Reagan Materials" in your makeup was a single piece of atom. From that little piece has arisen all this other stuff. But how long has it taken to get you where you are now? It has taken me, actually, over 78 years from conception to now. Oh, I have known for about 70 years that something was not right, and that at some point I would have to deal with it. But that little piece of quantum reality had to double, and double, and on and on. The life span of one of the misfolded pieces of protein is only about 2-4 hours, then it dies and is either urinated out or deposited in a tissue someplace. In the meantime, it has to double a couple times. But these clones are so tiny that the doubling has to take place billions of times before there is enough left over and deposited in your tissue that someone notices something amiss. And if yours is systemic, like mine, that means that instead of just having to produce enough misfolded protein to affect something tiny like a parathyroid or a lymph gland, you have a big fat old person. And that is why it takes so long to figure out what is the problem. The proteins only reproduce at a certain rate, and bigger people might have more tissue to fill with fibrils. And it is no wonder that it does not appear in recognizable form until you are 70-90 years old for most of us. So don't be too up tight. After all, it is unlikely I will die of this stuff. I have cancer all over my body, and diabetes, and lots of other stuff. Any of that can kill me before the proteins build up enough to endanger my life. Again, they call the English company "Bindings" because they deal with "Connective Tissue", the stuff that holds us together such as muscle and bone, or arteries and tendons, or ears and skulls. They call it "mixed" because hATTRwt is likely to show up anyplace. And laugh a lot. Some of this lot is pretty silly. I broke a toe putting a a stocking a couple months ago.