@trissi , Hello Trissi, welcome to our forum. I am glad that you found us. As Colleen has stated, alcohol and antibiotics do not go well together. I was always told that alcohol can kill the antibiotic's effectiveness. Another thing to consider is that the BIG 3 antibiotics can be hard on the liver, that is why they do routine liver function tests on you while taking them. You wouldn't want to tax the liver further with alcohol added to the mix. You are lucky in that you live not too far from the Mayo Clinic there. Have you considered being seen there?