Hi! I just joined and am anxious to share my experience with Effexor. After 27 years on a 60 mg daily dose of Prozac, I admitted myself to the hospital due to a major depressive episode that had me non functional, I was told by the psychiatrist that I was suffering from " Prozac poop out", which is what the medical community calls it. She weaned me off the Prozac while starting a 75 mg dose of Rffexor. I felt a change for the better literally in three days. I have been on Effexor for three months now, and in preparation for my family doctor visit next week, I had the routine blood work done that he always orders. I was shocked to see that my triglycerides have gone from 121 to an astounding 348, and my fasting blood sugar which has always been in the 90's is suddenly 123. I was also started on Jan 1 a combo BP pill of losartan/ hudrochlorothiazide. After eliminating white flour and white sugar for four days, my fasting sugar was 140 this morning. ( my husband is diabetic so I can test my sugars at home). I have been surfing WEB MD, and it appears that all of this could definitely be due to these two new meds. I desperately want to go back on Prozac and will be asking my doctor what to do as I DO NOT want to go on more meds for all of these side effects! Oh, and did I mention that it appears I am now full blown metabolism syndrome too! All of this and only THREE months on Effexor!